|
|
3alpha-hydroxy-3,5-dihydromonacolin_L_acid <=> monacolin_L_acid + H2O
|
1.14.14.124
dihydromonacolin L hydroxylase
|
–
|
| |
BRENDA:
BR51074
KEGG:
R10792
MetaCyc:
RXN-15672
|
|
|
|
dihydromonacolin_L_acid + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin_L_acid + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
not assigned
|
–
|
| |
MetaCyc:
RXN-15671
|
|
|
|
S-adenosyl-L-methionine + malonyl-CoA + holo-2-methylbutanoyl-[polyketide_synthase] + NADPH + H+ <=> (S)-2-methylbutanoyl-[2-methylbutanoate_polyketide_synthase] + S-adenosyl-L-homocysteine + CO2 + CoA + H2O + NADP+
|
2.3.1.244
2-methylbutanoate polyketide synthase
|
–
|
| |
MetaCyc:
RXN-15718
|
|
|
|
monacolin_L_acid + O2 + reduced_[NADPH-hemoprotein_reductase] <=> monacolin_J_acid + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.125
monacolin L hydroxylase
|
–
|
| |
MetaCyc:
RXN-15674
|
|
|
|
monacolin_J_acid + (S)-2-methylbutanoyl-[2-methylbutanoate_polyketide_synthase] <=> lovastatin_acid + holo-2-methylbutanoyl-[polyketide_synthase]
|
2.3.1.238
monacolin J acid methylbutanoate transferase
|
–
|
| |
MetaCyc:
RXN-15694
|
|
|
|
dihydromonacolin_L-[lovastatin_nonaketide_synthase] + H2O <=> lovastatin_nonaketide_synthase + dihydromonacolin_L_acid + H+
|
3.1.2.31
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
|
–
|
| |
MetaCyc:
RXN-15690
|
|
|
|
S-adenosyl-L-methionine + malonyl-CoA + lovastatin_nonaketide_synthase + NADPH + H+ <=> dihydromonacolin_L-[lovastatin_nonaketide_synthase] + S-adenosyl-L-homocysteine + CO2 + CoA + H2O + NADP+
|
2.3.1.161
lovastatin nonaketide synthase
|
–
|
| |
MetaCyc:
2.3.1.161-RXN
|
|
